Mechanical model for a collagen fibril pair in extracellular matrix
نویسندگان
چکیده
منابع مشابه
A mechanical model for collagen fibril load sharing in peripheral nerve of diabetic and nondiabetic rats.
Peripheral neuropathy affects approximately 50% of the 15 million Americans with diabetes. It has been suggested that mechanical effects related to collagen glycation are related to the permanence of neuropathy. In the present paper, we develop a model for load transfer in a whole nerve, using a simple pressure vessel approximation, in order to assess the significant of stiffening of the collag...
متن کاملExtracellular compartments in matrix morphogenesis: collagen fibril, bundle, and lamellar formation by corneal fibroblasts
The regulation of collagen fibril, bundle, and lamella formation by the corneal fibroblasts, as well as the organization of these elements into an orthogonal stroma, was studied by transmission electron microscopy and high voltage electron microscopy. Transmission and high voltage electron microscopy of chick embryo corneas each demonstrated a series of unique extracellular compartments. Collag...
متن کاملInfluence of fibril taper on the function of collagen to reinforce extracellular matrix.
Collagen fibrils provide tensile reinforcement for extracellular matrix. In at least some tissues, the fibrils have a paraboloidal taper at their ends. The purpose of this paper is to determine the implications of this taper for the function of collagen fibrils. When a tissue is subjected to low mechanical forces, stress will be transferred to the fibrils elastically. This process was modelled ...
متن کاملA Symmetrical, Extracellular Fibril
Symmetrical, extracellular fibrils, which are related to the "special fibrils" of the dermis described by Palade and Farquhar, have been found along the outer surface of the basement membrane covering the notochord in the tail of Rana catesbeiana (bullfrog) tadpoles. The fibrils are approximately 7,500 A long and occur singly or in clusters. The single fibrils are characterized by a symmetrical...
متن کاملCollagen fibril formation in a wound healing model.
Control of tissue composition and organization will be a key feature in the development of successful products through tissue engineering. However, the mechanism of collagen fibril formation, growth, and organization is not yet fully understood. In this study we have examined collagen fibril formation in a wound healing model in which the newly formed fibrils were kept distinct from preexisting...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Biophysics Journal
سال: 2009
ISSN: 0175-7571,1432-1017
DOI: 10.1007/s00249-008-0399-4